The best stretch of road I have driven, in NA, is the Sea to Sky highway in Vancouver heading North/NE thru Squamish and up towards Whistler. I worked the 2010 Olympic games and I had to drive that route every other day in a tour bus. Amazing scenery.
The drive from Banff to Vancouver is on my bucket list. Driving the up the Pacific Coast to Vancouver and then through the Rockies to Banff would be Amazing. But then I have to drive all the way back to LA from (basically) Calgary.