With the few cars I've had, none of them have any real issues with ethanol-blended fuel. As a matter of fact, the VW 1.8T actually seems to prefer E90, with the engine running a bit smoother and more rev happy. The only times when I have issues with ethanol fuel is when a car needs to be stored -- in my case, that's with winter storage. Regardless of whether fuel stabilizer is added or not, the engine is noticeably less happy with E90 gas (compared to "pure" gas when the same thing is done) in a much shorter time frame.
For me at least, fuel brands make a far more noticeable difference than whether the gas is ethanol blended or not. With the exception of my cheap D17 beater Civic, Esso gas almost always make my engines less "happy", and this applies to whether the car has been ECU-tuned or not. Shell V-Power / V-Power Nitro+, on the other hand, seems to be the preferred juice of choice for both my ECU-tuned Miata and Mazda2.
I've seen more people having issues with ethanol-blended gas on their bikes, but it has been too many years since I sold all my bikes, so other than the same ethanol blended gas vehicle storage issues that I've already mentioned, I don't remember what my gas experience with them are like.