Changing tire size

I have a 2006 mazda6 4 cyl. Not the S model. So my tires right now are 215/50/17. Can I change size? This size is hard to find and kind of pricey. I would like to go to a more standard tire size. Also can I just change two tires or do I have to do all 4 if I change to a different size?
thanks
 
225/45/17 would be the best plus 0 size to go with. very common size and adds little more width to it
 

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