To my knowledge, modern day cleaners when used properly are no worse for CCs than improperly combusted fuel created by poorly functioning / dirty injection an intake systems or oil blow-by. Improperly combusted fuel certainly washes down the cylinders and ends up in the motor oil. Fuel is an extremely poor lubricant. Which is why I could never understand these 'extended' OCIs and extended 'range' oils (marketing). The solution to pollution is dilution. Change your oil more often if anything, not less.
As implied above, what detergents are the "top-tier" brands blending in to their fuels? As such, why I specifically chose Chevron's Techron, you know, as a precaution...just in case.
Granted, a single small 12oz. bottle treats a bit more fuel than my 2010's tank holds, but it's fairly close. It is a concentrate after all and I certainly wouldn't recommend not following dilution directions at least somewhat closely with continued usage. I have no data or knowledge of what under dilution may or may not do.
No negative effects that I can see. Efficiency is still up, throttle response is still great, passes annual state emissions testing (on winter gas), and, is purring along like a new kitten better than ever at 91,000+ miles. All I need to know about it at this point.